CLTRN

Across TCGA pan-cancer cohorts, CLTRN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CLTRN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CLTRN RNA is repressed in tumor relative to normal tissue. In most cancer types CLTRN is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where CLTRN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLTRN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−5.840	<.001	11	view →
LIHC	Male	III,IV	−2.873	<.001	9	view →
THCA	Male	All	−0.655	<.001	7	view →
BRCA	Female	All	−0.489	<.001	6	view →
HNSC	All	All	+0.422	.004	6	view →
LUSC	Male	II,III,IV	−1.272	<.001	4	view →
COAD	All	All	+0.229	.011	4	view →
LUAD	Female	All	+0.621	.006	3	view →
STAD	All	II,III,IV	−0.593	.016	2	view →
PRAD	All	All	+0.230	.005	2	view →
BLCA	Male	IV	−0.617	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CLTRN–KICH

Open the KICH breakdown →