CLPX

Across TCGA cell cohorts, CLPX mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLPX-associated genes across cancer lineages are AVPR1B, FAM47C, and MGAT4D. Each is linked with CLPX in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPX-to-partner and partner-to-CLPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVPR1B grouped by CLPX-low versus CLPX-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPX→partner) and Y-score (partner→CLPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AVPR1B →	+0.013	+5.415	<.001	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	MGAT4D →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	LRRC3C →	+0.344	+3.777	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AVPR1B by CLPX expression — SKIN

Explore this box plot interactively →