CLIC5

Across TCGA patient cohorts, CLIC5 mutation is significantly associated with the RNA expression of many other genes, with 1,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC5-associated genes across cancer lineages are OR6C75, TTC39C-AS1, and OR10U1P. Each is linked with CLIC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLIC5-to-partner and partner-to-CLIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C75 grouped by CLIC5-low versus CLIC5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC5→partner) and Y-score (partner→CLIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR6C75 →	+0.050	+4.329	<.001	.001	3	3
UCEC	TTC39C-AS1 →	-0.710	-2.662	<.001	<.001	3	2
CESC	OR10U1P →	+0.030	+4.342	<.001	.007	3	2
UCEC	DLAT →	+0.500	+2.617	.007	.005	3	2
UCEC	ALPL →	-1.428	-2.799	<.001	.003	3	2
UCEC	WNT4 →	-0.697	-3.438	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,660 associations by consensus.

OR6C75 by CLIC5 expression — BLCA

Explore this box plot interactively →