CLIC5

Across TCGA pan-cancer cohorts, CLIC5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CLIC5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLIC5 RNA is repressed in tumor relative to normal tissue. In most cancer types CLIC5 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where CLIC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLIC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−4.084	<.001	12	view →
LUAD	Male	III,IV	−5.061	<.001	11	view →
KIRP	Female	II,III,IV	−4.452	<.001	11	view →
LUSC	Female	II,III,IV	−5.791	<.001	9	view →
KICH	Female	All	−4.417	<.001	9	view →
COAD	Female	All	−2.376	<.001	9	view →
HNSC	Male	All	−1.357	<.001	8	view →
LIHC	Female	All	+0.625	<.001	8	view →
READ	All	All	−2.269	<.001	7	view →
BRCA	All	III,IV	−1.760	<.001	6	view →
THCA	All	II,III,IV	−0.963	.001	5	view →
BLCA	Male	All	−0.876	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CLIC5–KIRC

Open the KIRC breakdown →