CLGN

Across TCGA cell cohorts, CLGN mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CLGN-associated genes across cancer lineages are IZUMO3, SCYGR2, and FASLG. Each is linked with CLGN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLGN-to-partner and partner-to-CLGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO3 grouped by CLGN-low versus CLGN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLGN→partner) and Y-score (partner→CLGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IZUMO3 →	+0.054	+4.969	<.001	.003	3	2
BLOOD_Myeloma	SCYGR2 →	+0.140	+4.807	<.001	.006	3	1
OVARY	FASLG →	+0.146	+4.392	<.001	.001	3	1
OVARY	MROH2B →	+0.044	+3.754	<.001	.002	3	1
OVARY	PAGE3 →	+0.016	+3.807	<.001	.009	3	1
SKIN	SERPINI2 →	+0.062	+3.758	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

IZUMO3 by CLGN expression — BLOOD_Leukemia

Explore this box plot interactively →