CLGN

Across TCGA pan-cancer cohorts, CLGN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CLGN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CLGN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLGN is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where CLGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	+4.660	<.001	10	view →
KIRP	All	III,IV	+2.286	<.001	9	view →
KIRC	Male	IV	+1.480	<.001	8	view →
BRCA	All	III,IV	+2.260	<.001	6	view →
HNSC	Female	II,III,IV	−0.824	.003	6	view →
COAD	All	All	−0.486	.001	6	view →
LUSC	All	All	+0.913	<.001	4	view →
READ	All	II,III,IV	−1.072	.014	2	view →
LIHC	All	All	+1.054	<.001	2	view →
PRAD	All	All	+0.875	<.001	2	view →
LUAD	All	All	+0.644	.003	2	view →
CHOL	Female	All	−1.333	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CLGN–KICH

Open the KICH breakdown →