CLEC4M

Across TCGA patient cohorts, CLEC4M mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC4M-associated genes across cancer lineages are STAT3_pY705, eIF4G, and p38-MAPK_pT180_Y182. Each is linked with CLEC4M in more than 2 cancer types. Because this analysis shows association rather than direction, both CLEC4M-to-partner and partner-to-CLEC4M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CLEC4M-low versus CLEC4M-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4M→partner) and Y-score (partner→CLEC4M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.359	-1.584	<.001	.019	3	3
SKCM	eIF4G →	+0.440	+1.700	.008	.043	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.421	-3.700	.004	.001	3	2
UCEC	ASNS →	+0.354	+2.115	.006	.017	3	2
UCEC	ATM →	-0.581	-2.906	<.001	.001	3	2
UCEC	BRCA2 →	-0.147	-3.416	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT3_pY705 by CLEC4M expression — UCEC

Explore this box plot interactively →