CLEC4M

Across TCGA pan-cancer cohorts, CLEC4M RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CLEC4M’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLEC4M RNA is repressed in tumor relative to normal tissue. In most cancer types CLEC4M is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where CLEC4M tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLEC4M RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.119	<.001	12	view →
COAD	Male	All	−0.233	<.001	10	view →
LIHC	Male	III,IV	−3.614	<.001	9	view →
LUSC	Female	All	−1.715	<.001	8	view →
LUAD	Female	III,IV	−1.483	<.001	8	view →
HNSC	Female	II,III,IV	+0.070	.002	8	view →
KICH	Male	II,III,IV	−0.172	<.001	7	view →
UCEC	All	All	−1.023	<.001	6	view →
BRCA	Female	II,III,IV	−0.184	<.001	6	view →
KIRP	Male	II,III,IV	−0.096	<.001	6	view →
CHOL	Male	All	−3.171	<.001	3	view →
THCA	All	All	−0.075	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CLEC4M–KIRC

Open the KIRC breakdown →