CLEC14A

Across TCGA cell cohorts, CLEC14A mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CLEC14A-associated genes across cancer lineages are KLK12, IFNA14, and BARHL2. Each is linked with CLEC14A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC14A-to-partner and partner-to-CLEC14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by CLEC14A-low versus CLEC14A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC14A→partner) and Y-score (partner→CLEC14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
OESOPHAGUS	BARHL2 →	+0.061	+4.017	<.001	.007	3	1
OESOPHAGUS	H1-8 →	+0.085	+4.857	<.001	<.001	3	1
OESOPHAGUS	H4C6 →	+0.294	+4.017	.001	.007	3	1
OESOPHAGUS	AFM →	+0.017	+4.392	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

KLK12 by CLEC14A expression — SOFT_TISSUE

Explore this box plot interactively →