CLDN23

Across TCGA patient cohorts, CLDN23 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,237 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLDN23-associated proteins across cancer lineages are CLDN23_S204, CLDN23_S203, and FRMD6_S544. Each is linked with CLDN23 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN23-to-partner and partner-to-CLDN23 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN23 versus CLDN23_S204 in BRCA, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN23→partner) and Y-score (partner→CLDN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLDN23_S204 →	+0.812	+1.188	<.001	<.001	3	5
PDAC	CLDN23_S203 →	+1.440	+1.713	<.001	<.001	3	5
LSCC	FRMD6_S544 →	-0.692	-0.664	<.001	<.001	3	4
PDAC	CLSTN1 →	-0.547	-0.994	<.001	<.001	3	4
GBM	STAT2 →	+0.394	+0.852	.007	<.001	3	3
GBM	THEMIS2 →	+0.594	+0.841	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,237 associations by consensus.

CLDN23 vs CLDN23_S204 — BRCA

Explore this scatter interactively →