CLDN23

Across TCGA pan-cancer cohorts, CLDN23 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CLDN23 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CLDN23 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CLDN23 expression acts as an unfavorable survival marker, although some lineages such as COAD and SKCM show a favorable association.

UVM, COAD, and SKCM are the cancer types where CLDN23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.362	0.890	<.001	82	view →
COAD	OS	Tertile	All	0.795	0.529	<.001	54	view →
SKCM	OS	Tertile	All	0.463	0.241	<.001	45	view →
LGG	OS	Median	All	0.367	0.523	<.001	40	view →
KIRC	DFS	Median	All	0.710	0.534	.001	33	view →
BLCA	DFS	Quartile	IV	0.553	0.352	.009	32	view →
ESCA	OS	Quartile	All	0.204	1.000	.005	26	view →
SARC	OS	Median	All	0.645	0.372	<.001	24	view →
THYM	DFS	Tertile	All	0.950	0.755	.003	22	view →
LUSC	OS	Tertile	All	0.550	0.711	.002	17	view →
STAD	DFS	Quartile	IV	0.218	0.694	.012	12	view →
MESO	DFS	Quartile	II,III,IV	0.138	0.632	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CLDN23–UVM (OS)

Open the UVM breakdown →