CLDN23

Across TCGA pan-cancer cohorts, CLDN23 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CLDN23’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CLDN23 RNA is repressed in tumor relative to normal tissue. In most cancer types CLDN23 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where CLDN23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLDN23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.998	<.001	11	view →
KICH	Male	II,III,IV	−1.633	<.001	10	view →
THCA	Male	All	−0.943	<.001	8	view →
READ	All	All	−2.880	<.001	7	view →
LUSC	All	II,III,IV	−1.279	<.001	7	view →
HNSC	All	II,III,IV	−0.950	<.001	7	view →
STAD	All	All	+1.245	.013	4	view →
BRCA	All	All	−0.378	<.001	4	view →
CHOL	All	All	+1.548	.005	2	view →
UCEC	All	All	+0.749	.011	2	view →
KIRP	Male	All	+0.554	.049	1	view →
LIHC	All	All	+0.261	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CLDN23–COAD

Open the COAD breakdown →