CLDN23

Across TCGA patient cohorts, CLDN23 protein abundance is significantly associated with the RNA expression of many other genes, with 4,871 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CLDN23-associated genes across cancer lineages are OSBPL10, PDXK, and FUT2. Each is linked with CLDN23 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN23-to-partner and partner-to-CLDN23 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN23 versus OSBPL10 in PDAC, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN23→partner) and Y-score (partner→CLDN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OSBPL10 →	-0.822	-0.821	<.001	.002	3	2
PDAC	PDXK →	-0.524	-0.841	.004	.003	3	2
CCRCC	FUT2 →	-0.341	-0.601	.001	.001	3	2
GBM	ZFYVE21 →	-0.819	-0.560	<.001	<.001	3	2
CCRCC	PAPLN →	-1.434	-0.759	<.001	.001	3	2
CCRCC	PLPPR3 →	-0.164	-0.728	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,871 associations by consensus.

CLDN23 vs OSBPL10 — PDAC

Explore this scatter interactively →