CLDN23

Across TCGA patient cohorts, CLDN23 mutation is significantly associated with the RNA expression of many other genes, with 739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN23-associated genes across cancer lineages are EIF4EBP2P3, RPL23P4, and PRR23D3P. Each is linked with CLDN23 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN23-to-partner and partner-to-CLDN23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4EBP2P3 grouped by CLDN23-low versus CLDN23-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN23→partner) and Y-score (partner→CLDN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4EBP2P3 →	+0.312	+3.542	<.001	.005	3	2
COAD	RPL23P4 →	+0.202	+3.321	<.001	.008	3	2
SKCM	PRR23D3P →	+0.116	+5.080	<.001	.004	3	2
CESC	SAPCD2P2 →	+0.036	+5.103	<.001	.008	3	1
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	1
CESC	ELAVL4-AS1 →	+0.051	+5.103	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

EIF4EBP2P3 by CLDN23 expression — COAD

Explore this box plot interactively →