CLDN18

Across TCGA patient cohorts, CLDN18 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,237 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLDN18-associated proteins across cancer lineages are PPP1R12B, KANK2, and LARP4_S583. Each is linked with CLDN18 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLDN18-to-partner and partner-to-CLDN18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN18 versus PPP1R12B in UCEC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN18→partner) and Y-score (partner→CLDN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R12B →	+0.730	+0.571	<.001	<.001	3	6
UCEC	KANK2 →	+0.524	+0.684	<.001	<.001	3	6
LUAD	LARP4_S583 →	-0.453	-1.768	<.001	<.001	3	6
UCEC	LMOD1_S85 →	+0.975	+0.554	<.001	.001	3	6
LSCC	LRP1 →	+0.402	+1.293	<.001	<.001	3	6
UCEC	FERMT2 →	+0.643	+0.660	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,237 associations by consensus.

CLDN18 vs PPP1R12B — UCEC

Explore this scatter interactively →