CLDN18

Across TCGA patient cohorts, CLDN18 protein abundance is significantly associated with the RNA expression of many other genes, with 5,365 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CLDN18-associated genes across cancer lineages are PIP5K1B, BTNL8, and TNNC1. Each is linked with CLDN18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN18-to-partner and partner-to-CLDN18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN18 versus PIP5K1B in PDAC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN18→partner) and Y-score (partner→CLDN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PIP5K1B →	+1.175	+2.030	<.001	<.001	3	3
PDAC	BTNL8 →	+1.351	+1.770	<.001	<.001	3	3
LSCC	TNNC1 →	+1.063	+0.644	<.001	<.001	3	3
PDAC	NR0B2 →	+1.421	+1.768	<.001	<.001	3	3
PDAC	C1QTNF6 →	-0.541	-2.137	<.001	<.001	3	3
PDAC	HMGCS2 →	+2.026	+1.510	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,365 associations by consensus.

CLDN18 vs PIP5K1B — PDAC

Explore this scatter interactively →