CLCN5

Across TCGA patient cohorts, CLCN5 protein abundance is significantly associated with the RNA expression of many other genes, with 4,290 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CLCN5-associated genes across cancer lineages are CRYL1, RPLP1P6, and CD27-AS1. Each is linked with CLCN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN5 versus CRYL1 in OV, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRYL1 →	+0.892	+1.013	.003	<.001	3	2
OV	RPLP1P6 →	-1.448	-1.111	.009	.004	3	2
OV	CD27-AS1 →	-1.282	-1.132	.003	.008	3	2
PDAC	TYRO3P →	-0.386	-0.877	.007	.004	3	2
BRCA	ABTB1 →	-0.836	-0.648	.002	<.001	3	2
BRCA	DOK7 →	-2.000	-0.668	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,290 associations by consensus.

CLCN5 vs CRYL1 — OV

Explore this scatter interactively →