CLCN5

Across TCGA pan-cancer cohorts, CLCN5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CLCN5’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where CLCN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLCN5 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

STAD, BLCA, and KICH are the cancer types where CLCN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Female	All	+1.342	<.001	11	view →
BLCA	All	All	+0.653	<.001	11	view →
KICH	Male	All	−2.187	<.001	10	view →
COAD	Male	All	+1.115	<.001	10	view →
KIRC	Male	All	−1.245	<.001	9	view →
THCA	Male	II,III,IV	−0.698	<.001	9	view →
READ	All	All	+0.985	<.001	7	view →
KIRP	Male	All	−1.059	<.001	6	view →
HNSC	All	All	+0.339	.002	5	view →
BRCA	All	II,III,IV	+0.336	<.001	4	view →
PRAD	All	All	+0.278	.001	2	view →
LUAD	All	All	−0.227	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CLCN5–STAD

Open the STAD breakdown →