CLCN3

Across TCGA patient cohorts, CLCN3 mutation is significantly associated with the RNA expression of many other genes, with 1,906 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN3-associated genes across cancer lineages are COX7A2, CYCSP26, and EDDM3DP. Each is linked with CLCN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN3-to-partner and partner-to-CLCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX7A2 grouped by CLCN3-low versus CLCN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3→partner) and Y-score (partner→CLCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX7A2 →	+0.326	+1.717	<.001	.003	3	3
SKCM	CYCSP26 →	+0.047	+4.678	<.001	.003	3	2
SKCM	EDDM3DP →	+0.062	+2.894	.002	.006	3	2
BRCA	UBQLN4P2 →	+0.022	+4.058	.001	.009	3	2
BRCA	STSP1 →	+0.015	+4.535	.007	.004	3	2
HNSC	RN7SL420P →	+0.149	+5.505	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,906 associations by consensus.

COX7A2 by CLCN3 expression — UCEC

Explore this box plot interactively →