CLASRP

Across TCGA cell cohorts, CLASRP mutation is significantly associated with the RNA expression of many other genes, with 654 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLASRP-associated genes across cancer lineages are NXF5, OR1L6, and SELP. Each is linked with CLASRP in more than 1 cancer types. Because this analysis shows association rather than direction, both CLASRP-to-partner and partner-to-CLASRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by CLASRP-low versus CLASRP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLASRP→partner) and Y-score (partner→CLASRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NXF5 →	+0.129	+3.710	<.001	.008	3	2
LUNG_SCLC	OR1L6 →	+0.038	+4.614	<.001	<.001	3	2
CNS	SELP →	+0.095	+3.774	<.001	.008	3	2
CNS	KLK15 →	+0.183	+4.584	<.001	.001	3	2
BREAST	S100G →	+0.375	+3.378	<.001	.006	3	2
LARGE_INTESTINE	C12orf65 →	+0.531	+3.064	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 654 associations by consensus.

NXF5 by CLASRP expression — LUNG_SCLC

Explore this box plot interactively →