CKMT1B

Across TCGA patient cohorts, CKMT1B mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKMT1B-associated genes across cancer lineages are Gab2, Notch1, and p27_pT157. Each is linked with CKMT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CKMT1B-to-partner and partner-to-CKMT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by CKMT1B-low versus CKMT1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKMT1B→partner) and Y-score (partner→CKMT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.459	+3.000	.019	.036	3	1
UCEC	Notch1 →	+0.230	+3.169	.002	.020	3	1
UCEC	p27_pT157 →	-0.072	-3.169	.024	.020	3	1
UCEC	PDK1 →	-0.121	-3.169	.040	.020	3	1
UCEC	Di-Ras3 →	-0.190	-3.169	.019	.020	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Gab2 by CKMT1B expression — UCEC

Explore this box plot interactively →