CKMT1B

Across TCGA pan-cancer cohorts, CKMT1B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CKMT1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CKMT1B RNA is repressed in tumor relative to normal tissue. In most cancer types CKMT1B is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, LUAD, and COAD are the cancer types where CKMT1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CKMT1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−1.330	<.001	12	view →
LUAD	Male	II,III,IV	+1.551	<.001	9	view →
COAD	All	All	−1.059	<.001	9	view →
LUSC	Male	All	+2.223	<.001	8	view →
BLCA	Male	IV	+2.162	.005	8	view →
KICH	Female	II,III,IV	+1.974	<.001	8	view →
UCEC	All	All	+1.784	<.001	8	view →
BRCA	All	II,III,IV	+0.612	<.001	6	view →
THCA	Male	All	−0.710	<.001	5	view →
PAAD	All	All	+1.757	.012	4	view →
LIHC	All	All	+0.158	.007	4	view →
READ	All	III,IV	−0.990	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CKMT1B–KIRC

Open the KIRC breakdown →