Across TCGA patient cohorts, CKLF RNA expression is significantly associated with the protein abundance of many other proteins, with 11,135 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CKLF-associated proteins across cancer lineages are MICAL1, CBFB, and VASH1_S313. Each is linked with CKLF in more than 4 cancer types. Because this analysis shows association rather than direction, both CKLF-to-partner and partner-to-CKLF results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CKLF→partner) and Y-score (partner→CKLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MICAL1 →	+0.317	+0.374	<.001	<.001	3	5
PDAC	CBFB →	+0.301	+0.633	<.001	<.001	3	5
BRCA	VASH1_S313 →	+0.624	+0.350	.001	.005	3	4
BRCA	NIFK →	-0.460	-0.398	<.001	<.001	3	4
LSCC	ARHGAP18 →	+0.326	+0.355	<.001	<.001	3	4
BRCA	STK10 →	+0.337	+0.431	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,135 associations by consensus.

Exploration

CKLF survival (RNA) · tumor vs normal (RNA) · all CKLF data types