Across TCGA pan-cancer cohorts, CKLF RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CKLF data layer compared with 1 for mass-spec protein.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CKLF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CKLF expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.
ACC, LIHC, and KIRP are the cancer types where CKLF RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.