CKLF-CMTM1

Across TCGA cell cohorts, CKLF-CMTM1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CKLF-CMTM1-associated genes across cancer lineages are MAGEB4, FTHL17, and CSN2. Each is linked with CKLF-CMTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CKLF-CMTM1-to-partner and partner-to-CKLF-CMTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CKLF-CMTM1-low versus CKLF-CMTM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKLF-CMTM1→partner) and Y-score (partner→CKLF-CMTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FTHL17 →	+0.060	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CSN2 →	+0.040	+4.684	<.001	.002	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.394	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MAGEB4 by CKLF-CMTM1 expression — LARGE_INTESTINE

Explore this box plot interactively →