CKLF-CMTM1

Across TCGA pan-cancer cohorts, CKLF-CMTM1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CKLF-CMTM1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CKLF-CMTM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CKLF-CMTM1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and LUAD are the cancer types where CKLF-CMTM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CKLF-CMTM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.420	<.001	12	view →
KIRP	All	II,III,IV	+0.874	<.001	11	view →
LUAD	Female	II,III,IV	+0.567	<.001	11	view →
BLCA	Male	All	+0.718	<.001	10	view →
KIRC	Male	All	+0.265	<.001	10	view →
COAD	Male	All	+0.447	<.001	9	view →
STAD	Male	II,III,IV	+0.783	<.001	8	view →
LIHC	All	III,IV	+0.123	<.001	8	view →
KICH	Female	All	−0.446	<.001	6	view →
BRCA	All	II,III,IV	+0.200	<.001	6	view →
THCA	All	All	+0.185	.002	4	view →
CHOL	Male	All	+0.656	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CKLF-CMTM1–HNSC

Open the HNSC breakdown →