CKLF-CMTM1

Across TCGA pan-cancer cohorts, CKLF-CMTM1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CKLF-CMTM1 data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher CKLF-CMTM1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CKLF-CMTM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

MESO, UVM, and PAAD are the cancer types where CKLF-CMTM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.278	0.500	.001	97	view →
UVM	DFS	Quartile	II,III,IV	0.298	0.795	.002	58	view →
PAAD	OS	Tertile	All	0.248	0.515	<.001	56	view →
HNSC	DFS	Median	IV	0.417	0.244	<.001	54	view →
LUSC	DFS	Median	II,III,IV	0.274	0.481	.004	45	view →
ACC	DFS	Quartile	All	0.518	0.911	.001	41	view →
LIHC	DFS	Quartile	All	0.441	0.601	.007	27	view →
UCS	DFS	Tertile	IV	0.936	0.488	.024	24	view →
LGG	OS	Quartile	All	0.694	0.847	.003	22	view →
BRCA	DFS	Median	III,IV	0.615	0.352	.002	18	view →
KICH	DFS	Quartile	II,III,IV	0.545	0.930	.028	17	view →
UCEC	DFS	Median	All	0.564	0.710	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CKLF-CMTM1–MESO (OS)

Open the MESO breakdown →