CKB

Across TCGA patient cohorts, CKB mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CKB-associated genes across cancer lineages are RNU6-835P, TBC1D3P4, and RN7SL496P. Each is linked with CKB in more than 2 cancer types. Because this analysis shows association rather than direction, both CKB-to-partner and partner-to-CKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-835P grouped by CKB-low versus CKB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKB→partner) and Y-score (partner→CKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-835P →	+0.358	+6.142	<.001	<.001	3	3
HNSC	TBC1D3P4 →	+0.046	+5.505	<.001	.004	3	2
HNSC	RN7SL496P →	+0.166	+6.111	<.001	.002	3	2
HNSC	LINC01974 →	+0.082	+5.578	<.001	.004	3	2
HNSC	MIR3664 →	+0.353	+5.655	.001	.004	3	2
COAD	CDRT15P2 →	+0.107	+6.409	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

RNU6-835P by CKB expression — COAD

Explore this box plot interactively →