CKB

Across TCGA pan-cancer cohorts, CKB RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CKB data layer compared with 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CKB RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CKB expression acts as an unfavorable survival marker, although some lineages such as KIRP and SCLC show a favorable association.

KIRP, THCA, and SCLC are the cancer types where CKB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.926	0.713	<.001	94	view →
THCA	DFS	Tertile	III,IV	0.632	0.948	<.001	65	view →
SCLC	OS	Median	All	0.816	0.586	.002	48	view →
KIRC	DFS	Quartile	IV	0.623	0.314	.010	17	view →
CESC	OS	Median	All	0.716	0.476	.007	16	view →
SKCM	DFS	Median	All	0.575	0.660	.008	12	view →
HNSC	OS	Median	IV	0.770	0.644	.007	12	view →
SARC	OS	Quartile	All	0.865	0.590	.001	12	view →
TGCT	DFS	Quartile	All	0.729	0.929	.023	10	view →
UVM	DFS	Tertile	All	0.408	0.668	.041	7	view →
UCS	DFS	Median	II,III,IV	0.589	0.291	.018	6	view →
STAD	DFS	Median	III,IV	0.576	0.256	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CKB–KIRP (DFS)

Open the KIRP breakdown →