CKB

Across TCGA cell cohorts, CKB mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CKB-associated genes across cancer lineages are OR5M8, OR8K3, and OR10W1. Each is linked with CKB in more than 1 cancer types. Because this analysis shows association rather than direction, both CKB-to-partner and partner-to-CKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M8 grouped by CKB-low versus CKB-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKB→partner) and Y-score (partner→CKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR5M8 →	+0.022	+5.754	<.001	.002	3	1
CNS	OR8K3 →	+0.013	+5.754	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DCD →	+0.043	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CLRN1 →	+0.012	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR5M8 by CKB expression — CNS

Explore this box plot interactively →