CIITA

Across TCGA patient cohorts, CIITA RNA expression is significantly associated with the protein abundance of many other proteins, with 17,246 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CIITA-associated proteins across cancer lineages are CD74, CORO1A, and HLA-DPB1. Each is linked with CIITA in more than 9 cancer types. Because this analysis shows association rather than direction, both CIITA-to-partner and partner-to-CIITA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIITA versus CD74 in HNSC, with a Pearson correlation of 0.75.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIITA→partner) and Y-score (partner→CIITA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD74 →	+0.863	+1.147	<.001	<.001	3	10
UCEC	CORO1A →	+0.703	+0.896	<.001	<.001	3	10
GBM	HLA-DPB1 →	+0.694	+0.663	<.001	<.001	3	10
GBM	HLA-DRA →	+0.933	+0.912	<.001	<.001	3	10
UCEC	HLA-DRB1 →	+0.813	+0.840	<.001	<.001	3	10
HNSC	ITGAL →	+0.660	+1.293	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,246 associations by consensus.

CIITA vs CD74 — HNSC

Explore this scatter interactively →