CIITA

Across TCGA pan-cancer cohorts, CIITA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CIITA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CIITA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CIITA is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where CIITA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CIITA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.100	<.001	11	view →
LUAD	Male	All	−0.908	<.001	8	view →
LUSC	Male	II,III,IV	−1.673	<.001	6	view →
STAD	All	All	+0.973	.003	6	view →
LIHC	Female	All	+0.631	.001	6	view →
THCA	Male	II,III,IV	+0.917	.019	3	view →
CHOL	All	All	+1.498	.005	2	view →
UCEC	All	All	−0.656	.032	2	view →
KICH	All	II,III,IV	−0.513	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CIITA–KIRC

Open the KIRC breakdown →