CIITA

Across TCGA pan-cancer cohorts, CIITA RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CIITA data layer compared with 9 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CIITA RNA is associated with better overall survival. In most high-consensus cancer types, elevated CIITA expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LGG are the cancer types where CIITA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.429	0.270	<.001	117	view →
HNSC	DFS	Median	All	0.769	0.649	<.001	92	view →
LGG	DFS	Median	All	0.636	0.836	<.001	54	view →
BLCA	OS	Quartile	IV	0.726	0.456	.001	49	view →
BRCA	OS	Median	III,IV	0.893	0.764	.003	45	view →
LIHC	DFS	Median	II,III,IV	0.421	0.215	.001	43	view →
READ	OS	Median	II,III,IV	0.943	0.470	.001	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LUAD	OS	Median	All	0.739	0.634	.003	32	view →
THYM	DFS	Quartile	All	0.771	1.000	<.001	26	view →
UVM	OS	Quartile	All	0.431	0.853	.009	24	view →
SCLC	DFS	Tertile	All	0.774	0.467	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CIITA–SKCM (OS)

Open the SKCM breakdown →