CIITA

Across TCGA patient cohorts, CIITA protein abundance is significantly associated with the go_rna of many other GO terms, with 84 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CIITA-associated GO terms across cancer lineages are Neuron projection extension, Regulation of neural precursor cell proliferation, and Reactive nitrogen species metabolic process. Each is linked with CIITA in more than 1 cancer types. Because this analysis shows association rather than direction, both CIITA-to-partner and partner-to-CIITA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuron projection extension grouped by CIITA-low versus CIITA-high in BRCA.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIITA→partner) and Y-score (partner→CIITA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Neuron projection extension →	+0.054	+2.061	<.001	.004	3	1
BRCA	Regulation of neural precursor cell proliferation →	+0.047	+1.572	.007	.003	3	1
BRCA	Reactive nitrogen species metabolic process →	+0.071	+2.199	.005	.005	3	1
BRCA	Regulation of cell size →	+0.054	+3.198	<.001	.003	3	1
BRCA	Regulation of platelet aggregation →	+0.097	+2.286	.005	.006	3	1
BRCA	Cellular lipid biosynthetic process →	+0.060	+1.426	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Neuron projection extension by CIITA expression — BRCA

Explore this box plot interactively →