CIITA

Across TCGA patient cohorts, CIITA mutation is significantly associated with the RNA expression of many other genes, with 6,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIITA-associated genes across cancer lineages are NADK2, HMG20B, and AOC2. Each is linked with CIITA in more than 4 cancer types. Because this analysis shows association rather than direction, both CIITA-to-partner and partner-to-CIITA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NADK2 grouped by CIITA-low versus CIITA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIITA→partner) and Y-score (partner→CIITA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NADK2 →	+0.424	+1.860	.004	.004	3	5
UCEC	HMG20B →	+0.565	+1.698	<.001	<.001	3	5
UCEC	AOC2 →	+0.868	+2.137	<.001	<.001	3	5
UCEC	CHAF1A →	+0.586	+1.928	<.001	<.001	3	5
COAD	SPATA5L1 →	+0.426	+2.666	<.001	.005	3	5
UCEC	SLC25A33 →	+0.657	+1.698	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,115 associations by consensus.

NADK2 by CIITA expression — SKCM

Explore this box plot interactively →