CIITA

Across TCGA patient cohorts, CIITA mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIITA-associated genes across cancer lineages are C-Raf, Chk2_pT68, and JNK_pT183_Y185. Each is linked with CIITA in more than 2 cancer types. Because this analysis shows association rather than direction, both CIITA-to-partner and partner-to-CIITA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CIITA-low versus CIITA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIITA→partner) and Y-score (partner→CIITA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.209	+2.493	<.001	.009	3	3
UCEC	Chk2_pT68 →	-0.178	-3.990	.003	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.129	-1.584	.020	.034	3	3
UCEC	MEK1 →	+0.354	+2.662	.003	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.375	-2.000	.011	.009	3	3
UCEC	PDK1_pS241 →	+0.129	+1.765	.022	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

C-Raf by CIITA expression — COAD

Explore this box plot interactively →