CIITA

Across TCGA cell cohorts, CIITA mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CIITA-associated genes across cancer lineages are LRRC3C, SEPTIN3, and ZCCHC2. Each is linked with CIITA in more than 2 cancer types. Because this analysis shows association rather than direction, both CIITA-to-partner and partner-to-CIITA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by CIITA-low versus CIITA-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIITA→partner) and Y-score (partner→CIITA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LRRC3C →	+0.041	+3.428	.002	.008	3	3
LARGE_INTESTINE	SEPTIN3 →	+1.057	+3.082	.005	.007	3	2
LARGE_INTESTINE	ZCCHC2 →	+0.962	+3.067	<.001	.009	3	2
LARGE_INTESTINE	YES1 →	+0.770	+3.169	.001	.009	3	2
BLOOD_Leukemia	KSR2 →	+0.285	+2.891	<.001	<.001	3	2
BLOOD_Leukemia	RBP3 →	+0.014	+2.339	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

LRRC3C by CIITA expression — STOMACH

Explore this box plot interactively →