CIAO1

Across TCGA patient cohorts, CIAO1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,263 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CIAO1-associated genes across cancer lineages are GHR, CXCR1, and CXCR2. Each is linked with CIAO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CIAO1-to-partner and partner-to-CIAO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIAO1 versus GHR in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO1→partner) and Y-score (partner→CIAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GHR →	-0.919	-0.127	.004	.005	3	4
LSCC	CXCR1 →	-1.012	-0.219	<.001	<.001	3	4
PDAC	CXCR2 →	-0.960	-0.160	<.001	.002	3	4
BRCA	PLEKHH2 →	-0.985	-0.168	<.001	.001	3	4
UCEC	CACNA1C →	-0.888	-0.209	<.001	<.001	3	4
CCRCC	AFAP1L1 →	-0.960	-0.233	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,263 associations by consensus.

CIAO1 vs GHR — BRCA

Explore this scatter interactively →