CHST8

Across TCGA patient cohorts, CHST8 mutation is significantly associated with the RNA expression of many other genes, with 908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST8-associated genes across cancer lineages are RNU6-1318P, RN7SL591P, and SFRP5. Each is linked with CHST8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHST8-to-partner and partner-to-CHST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by CHST8-low versus CHST8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST8→partner) and Y-score (partner→CHST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1318P →	+0.231	+2.358	<.001	.004	3	3
COAD	RN7SL591P →	+0.239	+4.392	.001	.006	3	3
UCEC	SFRP5 →	-0.902	-3.574	.005	.002	3	3
STAD	RNU6-13P →	+0.439	+2.823	.001	.006	3	3
SARC	RN7SL447P →	+0.282	+5.345	<.001	.005	3	3
SKCM	RNU1-73P →	+0.277	+3.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

RNU6-1318P by CHST8 expression — UCEC

Explore this box plot interactively →