CHST8

Across TCGA pan-cancer cohorts, CHST8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CHST8 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHST8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHST8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

KIRC, LUAD, and UCS are the cancer types where CHST8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.232	0.655	<.001	84	view →
LUAD	DFS	Quartile	All	0.899	0.719	.001	48	view →
UCS	DFS	Tertile	II,III,IV	0.580	0.160	.006	24	view →
BLCA	OS	Median	IV	0.244	0.567	.017	22	view →
UVM	DFS	Median	II,III,IV	0.353	0.605	.013	20	view →
READ	DFS	Quartile	All	0.423	0.821	.003	14	view →
OV	OS	Quartile	II,III,IV	0.800	0.890	.018	14	view →
HNSC	DFS	Tertile	IV	0.728	0.547	.006	12	view →
PAAD	DFS	Quartile	All	0.479	0.259	.012	12	view →
GBM	OS	Tertile	All	0.320	0.492	.011	9	view →
LGG	DFS	Quartile	All	0.635	0.822	.007	8	view →
KIRP	OS	Quartile	All	0.607	0.793	.033	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CHST8–KIRC (DFS)

Open the KIRC breakdown →