CHRM4

Across TCGA patient cohorts, CHRM4 mutation is significantly associated with the RNA expression of many other genes, with 2,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRM4-associated genes across cancer lineages are KCNRG, GTF2A2, and FUT10. Each is linked with CHRM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRM4-to-partner and partner-to-CHRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNRG grouped by CHRM4-low versus CHRM4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM4→partner) and Y-score (partner→CHRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KCNRG →	+0.515	+3.249	.001	.008	3	3
STAD	GTF2A2 →	+0.875	+3.236	<.001	.009	3	3
STAD	FUT10 →	+0.666	+3.203	<.001	.009	3	3
STAD	TYMS →	+1.020	+3.203	<.001	.009	3	3
COAD	KCTD9 →	+0.724	+3.223	.004	.009	3	3
COAD	SLC17A5 →	+0.769	+3.223	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,085 associations by consensus.

KCNRG by CHRM4 expression — COAD

Explore this box plot interactively →