CHRM4

Across TCGA pan-cancer cohorts, CHRM4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHRM4’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where CHRM4 RNA is repressed in tumor relative to normal tissue. In most cancer types CHRM4 is over-expressed in tumor, although a few such as STAD and COAD show the opposite, repressed pattern.

STAD, KIRP, and COAD are the cancer types where CHRM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHRM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.819	<.001	8	view →
KIRP	All	All	+0.463	.004	7	view →
COAD	All	II,III,IV	−0.778	<.001	6	view →
LUAD	All	All	−0.633	<.001	6	view →
HNSC	Male	All	+0.330	.012	4	view →
BRCA	All	II,III,IV	+0.259	.001	4	view →
KIRC	All	All	+0.248	.006	4	view →
LIHC	All	All	+0.118	.006	4	view →
READ	All	All	−1.256	<.001	3	view →
KICH	All	II,III,IV	+0.290	.015	2	view →
CHOL	All	All	+0.122	.004	2	view →
LUSC	All	III,IV	−0.578	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHRM4–STAD

Open the STAD breakdown →