CHRM3-AS2

Across TCGA pan-cancer cohorts, CHRM3-AS2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CHRM3-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHRM3-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHRM3-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where CHRM3-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.799	0.705	<.001	96	view →
BRCA	DFS	Median	All	0.624	0.451	<.001	69	view →
SKCM	OS	Median	All	0.432	0.241	<.001	66	view →
BLCA	OS	Median	IV	0.684	0.495	.001	64	view →
LGG	OS	Median	All	0.737	0.860	<.001	51	view →
CESC	OS	Median	All	0.876	0.720	<.001	42	view →
READ	OS	Median	II,III,IV	0.851	0.393	.001	38	view →
GBM	DFS	Median	All	0.178	0.316	<.001	30	view →
CHOL	DFS	Tertile	All	0.708	0.128	<.001	26	view →
KIRP	DFS	Quartile	II,III,IV	0.159	0.690	.001	25	view →
PAAD	OS	Tertile	II,III,IV	0.691	0.496	.010	20	view →
UVM	DFS	Quartile	III,IV	0.276	0.622	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CHRM3-AS2–HNSC (OS)

Open the HNSC breakdown →