CHRD

Across TCGA patient cohorts, CHRD protein abundance is significantly associated with the RNA expression of many other genes, with 5,852 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHRD-associated genes across cancer lineages are THPO, GAR1, and KCNE4. Each is linked with CHRD in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRD-to-partner and partner-to-CHRD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRD versus THPO in BRCA, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRD→partner) and Y-score (partner→CHRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THPO →	+1.039	+0.723	<.001	<.001	3	5
UCEC	GAR1 →	-0.403	-0.286	.002	.002	3	4
BRCA	KCNE4 →	+1.895	+0.685	<.001	<.001	3	4
CCRCC	SLC1A7 →	+0.978	+0.699	<.001	.003	3	4
BRCA	PDZRN4 →	+0.648	+0.592	.004	<.001	3	4
UCEC	KCNK3 →	+0.930	+0.529	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,852 associations by consensus.

CHRD vs THPO — BRCA

Explore this scatter interactively →