CHRD

Across TCGA pan-cancer cohorts, CHRD RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CHRD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CHRD RNA is repressed in tumor relative to normal tissue. In most cancer types CHRD is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and BRCA are the cancer types where CHRD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHRD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.358	<.001	10	view →
UCEC	All	All	−2.078	<.001	6	view →
BRCA	All	All	+0.450	.002	6	view →
HNSC	Female	All	+0.780	.012	5	view →
THCA	Female	All	−0.348	<.001	5	view →
KIRP	All	All	−0.733	.002	3	view →
PRAD	All	All	+0.715	<.001	2	view →
BLCA	All	All	−0.537	.034	2	view →
LUAD	All	All	+0.280	.033	2	view →
CHOL	All	All	−1.205	.045	1	view →
READ	Female	All	−0.532	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CHRD–KICH

Open the KICH breakdown →