CHPF

Across TCGA patient cohorts, CHPF mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHPF-associated genes across cancer lineages are mTOR_pS2448, 14-3-3_beta, and EGFR_pY1068. Each is linked with CHPF in more than 2 cancer types. Because this analysis shows association rather than direction, both CHPF-to-partner and partner-to-CHPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CHPF-low versus CHPF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHPF→partner) and Y-score (partner→CHPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.128	-2.308	.043	.033	3	2
UCEC	14-3-3_beta →	-0.128	-3.295	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.336	-4.000	.001	<.001	3	1
UCEC	ERK2 →	+0.205	+2.999	.012	.035	3	1
UCEC	ACC1 →	+0.396	+3.013	.010	.018	3	1
UCEC	Heregulin →	-0.158	-3.156	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

mTOR_pS2448 by CHPF expression — UCEC

Explore this box plot interactively →