CHPF

Across TCGA cell cohorts, CHPF mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHPF-associated genes across cancer lineages are DEFB124, KRT71, and REG3G. Each is linked with CHPF in more than 1 cancer types. Because this analysis shows association rather than direction, both CHPF-to-partner and partner-to-CHPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by CHPF-low versus CHPF-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHPF→partner) and Y-score (partner→CHPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	2
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.162	+4.867	<.001	.009	3	1
BREAST	MYF5 →	+0.023	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	LGALS13 →	+0.458	+3.947	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DEFB124 by CHPF expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →