CHN1

Across TCGA patient cohorts, CHN1 mutation is significantly associated with the RNA expression of many other genes, with 1,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHN1-associated genes across cancer lineages are GAGE13, CATSPER3, and LSM12. Each is linked with CHN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHN1-to-partner and partner-to-CHN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE13 grouped by CHN1-low versus CHN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHN1→partner) and Y-score (partner→CHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAGE13 →	+0.076	+5.727	<.001	.001	3	2
UCEC	CATSPER3 →	+0.363	+3.191	.002	.009	3	2
UCEC	LSM12 →	+0.531	+3.362	.005	.005	3	2
UCEC	CHAF1A →	+0.772	+3.021	<.001	<.001	3	2
UCEC	STX8 →	+0.488	+3.010	<.001	<.001	3	2
UCEC	COX10 →	+0.404	+3.000	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,566 associations by consensus.

GAGE13 by CHN1 expression — BRCA

Explore this box plot interactively →