CHN1

Across TCGA pan-cancer cohorts, CHN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CHN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHN1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where CHN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.952	<.001	12	view →
KICH	Male	II,III,IV	−1.181	<.001	10	view →
LIHC	All	II,III,IV	+0.888	<.001	9	view →
COAD	Female	All	+0.706	<.001	8	view →
LUSC	All	All	−0.548	<.001	7	view →
KIRC	All	All	+0.453	<.001	7	view →
CHOL	All	All	+1.180	<.001	3	view →
LUAD	Female	III,IV	−1.031	.006	3	view →
UCEC	All	All	−0.737	.017	2	view →
PRAD	All	All	−0.690	<.001	2	view →
ESCA	All	All	+1.211	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CHN1–HNSC

Open the HNSC breakdown →