CHN1

Across TCGA pan-cancer cohorts, CHN1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CHN1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

ACC, MESO, and UVM are the cancer types where CHN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.284	0.638	<.001	136	view →
MESO	OS	Quartile	All	0.211	0.562	<.001	81	view →
UVM	DFS	Tertile	II,III,IV	0.264	0.627	.004	47	view →
HNSC	DFS	Tertile	II,III,IV	0.410	0.225	.004	42	view →
STAD	DFS	Median	All	0.319	0.469	.010	34	view →
LUAD	OS	Tertile	III,IV	0.835	0.442	<.001	28	view →
UCEC	DFS	Quartile	All	0.481	0.734	.007	26	view →
LIHC	OS	Median	III,IV	0.608	0.195	<.001	24	view →
KIRP	OS	Quartile	II,III,IV	0.292	0.630	.023	20	view →
THCA	DFS	Tertile	II,III,IV	0.944	0.794	.020	15	view →
CESC	DFS	Median	All	0.780	0.861	.006	14	view →
SKCM	OS	Quartile	All	0.436	0.269	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CHN1–ACC (DFS)

Open the ACC breakdown →